Hydroxymethyl Resin, 200-400 mesh, 0.5-1.5 mmol/g

Catalog Number	ACMA00046633
Description	This resin is ideal for the solid phase immobilization of carboxylic acids. During the attachment of diacids less cross-linking is observed in comparison to Merrifield resin. Reaction with a suitable phosgene equivalent converts this resin to a support suitable for the immobilization of amines. The carbamate linker of hydroxymethyl polysterene can be used as an equivalent of Cbz, is stable to a wide range of acidic, basic and reductive conditions. Fisher indole synthesis and Pictet-Spengler cyclization on solid support, which require 70ºC in acetic acid with zinc cloride and 10% TFA in dichloromethane, respectively, were successfully carried out using this linker. Methyl esters can be produced by transesterification with MeONa or Ti(OEt)4/C2H5CO2Me. Carboxamides are also accessible via Lewis acid catalyzed aminolysis. Highly pure ketopiperazines can be produced by the resin-bound alpha-amino acids.
Cross Link	0.01 (DVB)
Functional Group	OH Functionalized Resins
Loading	0.5-1.5 mmol/g
Packaging	5g/25g/100g
Particle Size	200-400 mesh