Detection of Organic Acid by Ion Chromatography


Organic acids refer to some organic compounds with acidity. They are widely found in biomass, food materials and medicines. Alfa Chemistry uses chromatographic analysis to detect organic acids in samples. Our testing is carried out under strict operating standards, which can ensure the accuracy of the testing results. Just tell us your test requirements, we will return you a high-quality test report.


There are many methods for determining organic acids, and the common ones are spectrophotometry, gas chromatography, liquid chromatography, ion chromatography, nuclear magnetic resonance spectroscopy, capillary electrophoresis, etc. Traditional detection methods such as spectrophotometry have cumbersome steps and need to be measured one by one, which requires a large amount of work and a long detection cycle. Ion chromatography is the most promising detection method, which is suitable for simultaneous detection of multiple ionic compounds in samples. In medicine, the most common organic acids are sulfuric acid, phosphoric acid, hydrochloric acid, nitric acid, acetic acid, citric acid, maleic acid, and hydrobromic acid. The chemical polishing liquid contains formic acid, oxalic acid, tartaric acid, nitrilotriacetic acid, etc. Organic acids in fruit juice drinks include lactic acid, fumaric acid, n-butyric acid, succinic acid, pyruvic acid and so on. These organic acids containing coordination groups in the elemental composition can be used to determine their content indirectly by detecting the coordination groups by ion chromatography.

Detection of Organic acid by ion chromatography

Experimental condition screening

  • Optimization of chromatographic conditions
  • The first is the concentration of the eluent. When the flow rate is constant, by adjusting the concentration of the eluent, observe the peak splitting situation in the chromatogram, and select the elution concentration with the best peak splitting effect and the faster peak. The second is the choice of flow rate. The flow rate will affect the peaking speed and peak splitting effect, so it also needs to be optimized.

  • Optimization of separation conditions
  • Since the components of the sample to be tested are often more complicated, it is necessary to perform interference analysis on the coexisting ions that may exist in the sample to be tested. The coexisting ions can be mixed with the target standard solution and then injected, and the ion chromatogram can be observed.

Alfa Chemistry is the guarantee of quality. We have many years of experience in ion chromatography analysis, and have helped many companies and individuals complete their test projects, which have been well received by customers. We always believe that only high-quality services are the most competitive in the market. Our customers can directly contact our experts and provide timely feedback on any online inquiries. If you are interested in our services, please contact us.

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